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Alternative Sweetener Linked to Liver Disease — ice with cherry on top

Alternative Sweetener Linked to Liver DiseaseCEFR B1

28 Nov 2025

Adapted from Washington U. in St. Louis, Futurity CC BY 4.0

Photo by Myriam Zilles, Unsplash

AI-assisted adaptation of the original article, simplified for language learners.

Recent studies have revealed significant health concerns regarding the sugar substitute sorbitol. Often found in low-calorie foods, sorbitol can be converted to fructose in the liver, where it may contribute to liver disease. This transformation occurs especially when glucose levels are high, meaning excessive intake of glucose can lead to higher sorbitol production in the gut.

Research indicates that while some gut bacteria help break down sorbitol, an overload of sorbitol can prevent this process. The resulting accumulation in the liver raises concerns about liver dysfunction and associated health risks. Sorbitol’s harmful potential is becoming increasingly apparent, challenging the notion that all sugar substitutes are healthier choices.

The research team plans to continue investigating how different types of bacteria interact with sorbitol. Their findings suggest that the old adage of "no free lunch" holds true when exploring sugar alternatives, pointing toward a need for cautious dietary choices.

Difficult words

  • sorbitolA sugar substitute used in low-calorie foods.
  • transformTo change from one form to another.
    transformation, converted
  • accumulationThe gradual gathering of something.
  • dysfunctionAbnormal or impaired functioning.
  • alternativeOther choices or options.
    alternatives
  • concernA matter that worries someone.
    concerns

Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.

Discussion questions

  • What are your thoughts on sugar substitutes?
  • How can people make better dietary choices?
  • Why do you think research on food ingredients is important?

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