Researchers at the University of Chicago created GA1CAR, a modular CAR-T system that uses short-lived Fab fragments to guide and pause tumor targeting. In animal tests the same cells were redirected to different tumors and remained functional.
Photo by National Institute of Allergy and Infectious Diseases, Unsplash
Scientists paired rifampicin with a probe called AAP-SO2 that binds bacterial RNA polymerase at a different site and slows transcription. The pair killed resistant mutants in culture and was especially effective in a rabbit model.
In 2020 a PhD student and her adviser at UC Santa Barbara developed an algae-based synthetic membrane to support mammary epithelial cells. Their tunable gel, reported in Science Advances, can direct cell growth by changing mechanical and biochemical cues.
A research team created changed antibodies that stop human cytomegalovirus from disabling immune responses. Lab tests show the antibodies reduce virus spread, but researchers say more testing is needed before they can be used in people.
Researchers at Brown University report that blocking the mTORC2 protein complex, while leaving mTORC1 active, may stop cancer growth signals without triggering survival pathways. The work offers a new direction for designing cancer drugs.
A study in The American Journal of Psychiatry found lower availability of a glutamate receptor called mGlu5 across the brains of autistic adults. Researchers used PET, MRI and EEG and say the result could affect future diagnosis and treatment.
