Researchers report that sorbitol can be converted to fructose in the liver and may contribute to liver disease. The work was led by Gary Patti at Washington University and published in Science Signaling.
Scientists used zebrafish to trace how sorbitol moves from the gut into the body. Sorbitol can come from foods, such as some low-calorie candies, gums and some fruits, or it can be made from glucose in the intestine when glucose is high.
Gut bacteria, including Aeromonas strains, can break down sorbitol. If those bacteria are absent or overwhelmed, sorbitol can reach the liver and become a fructose derivative with possible harm. The study was supported by the National Institutes of Health.
Difficult words
- sorbitol — A type of sugar used in food products.
- conversion — Changing one substance into another.
- fructose — A type of sugar found in many foods.
- liver — An important organ that processes substances in the body.the liver
- bacteria — Tiny living things that can help or harm health.
- health — The state of being free from illness.
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- What other foods might contain sorbitol?
- How can you reduce fructose intake?
- Why is it important to understand how sugar alcohols work?
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