Alternative splicing linked to mammal lifespan ^{CEFR A2}

Researchers published a study in Nature Communications that compares alternative splicing across 26 mammal species with maximum lifespans from 2.2 to 37 years (>16-fold differences). Alternative splicing is a process where one gene can make different mRNA and proteins by including or skipping segments. The team looked at six tissue types, including the brain, and found many splicing patterns linked to lifespan that are shared across species.

The brain showed twice as many lifespan-linked splicing events than other tissues. The researchers found that splicing predicts maximum lifespan better than simple differences in gene activity. They also found that RNA-binding proteins genetically control lifespan-linked splicing rather than it being a simple byproduct of aging.

Co-authors include Sika Zheng at the University of California, Riverside School of Medicine and Liang Chen at the University of Southern California. The National Institutes of Health funded the research.