Researchers at Brown University report that blocking the mTORC2 protein complex, while leaving mTORC1 active, may stop cancer growth signals without triggering survival pathways. The work offers a new direction for designing cancer drugs.
Photo by National Cancer Institute, Unsplash
Scientists found a mechanical "tipping point" that makes groups of cells switch quickly from healthy to fibrotic states. Collagen fibers, cell spacing and crosslinking control this abrupt change and affect how far mechanical signals travel.
A study in Nature Communications compared alternative splicing across 26 mammal species (lifespans 2.2–37 years) and found splicing patterns better predict maximum lifespan than gene activity; the brain shows many lifespan-linked events controlled by RNA-binding proteins.
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