Researchers at a laboratory at Rockefeller University found that memory persistence is regulated by multiple molecular timers. The timers act across different brain regions rather than at a single site. The team identified an unexpected node in this process, the thalamus.
The thalamus appears to help move memories from short-term storage toward long-term storage. The lab linked the thalamus to gene programs that progressively stabilise individual memories. The study shows a sequence of molecular events that unfold in time and space, and each step helps make a memory more stable.
This new framework changes how researchers think about memory formation and may open the door to new approaches for treating memory disorders, including Alzheimer’s, although clinical implications remain to be determined.
Difficult words
- memory — information a person can remembermemories
- persistence — continuing over time without stopping
- regulate — control or manage a process or activityregulated
- molecular — relating to very small parts of cells
- thalamus — part of the brain between cortex and other areas
- stabilise — make something stronger or more steady
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Why is it important to move memories from short-term to long-term storage?
- How could changes in these molecular timers affect a person with memory problems?
- What new approaches for treating memory disorders might researchers try after this study?
Related articles
Dopamine helps lock in new skills during sleep
A study from the University of Michigan finds that dopamine neurons become active during NREM sleep soon after a person learns a movement. Their activity, together with sleep spindles, strengthens motor memories and improves skills after sleep.
LLMs change judgments when told who wrote a text
Researchers at the University of Zurich found that large language models change their evaluations of identical texts when given an author identity. The study tested four models and warns about hidden biases and the need for governance.
Brain differences in WTC responders with PTSD
New imaging research of World Trade Center responders finds measurable brain structure differences linked to long-term PTSD. Researchers used gray-white contrast (GWC) MRI and other markers to distinguish responders with and without PTSD.
Lack of African research weakens policy and trade
The African Academy of Sciences warns that too little scientific evidence produced in Africa makes policy and trade harder. The AAS is building networks, starting a science diplomacy programme and trying to restore trust after funding problems.