Researchers at Washington University in St. Louis built a new computational tool called MITE (pronounced "mighty") to study how cells in the suprachiasmatic nucleus (SCN) communicate. They used weeks-long recordings of gene expression with cellular resolution in mice to map connections among cells.
The maps showed that only a small group of highly connected hub cells is essential for synchrony. The team identified five functional cell types, including hub cells, bridge cells that relay signals, and sink cells that receive timing information and likely send it to the rest of the body.
Computer simulations that removed hub neurons caused network synchrony to collapse. The researchers say the tool could help develop ways to realign the body clock and assist shift workers and people with seasonal affective disorder.
Difficult words
- computational — related to using computers to study data
- suprachiasmatic nucleus — a small brain area that controls body clock
- gene expression — process where genes create molecules inside cells
- synchrony — when parts act or work at the same time
- simulation — a computer model that copies real eventssimulations
- hub cell — a cell with many connections to othershub cells
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Have you ever worked at night? How did it affect your sleep?
- Would you use a tool that helps your body clock? Why or why not?
- Why are hub cells important, based on the article?
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