New research suggests that adding antibodies produced after infection could improve influenza vaccines by reducing how much infected people spread the virus. The study highlights antibodies to neuraminidase (NA) and two parts of hemagglutinin, the HA head and HA stalk, as offering extra community protection beyond preventing illness.
A multinational team followed 171 Nicaraguan households and their contacts over three influenza seasons. Using blood tests, virologic testing and mathematical modelling, the researchers identified which antibodies most effectively limited household spread. Most participants had never been vaccinated, so the study observed transmission driven largely by infection-acquired immunity.
The authors note that infection-derived immunity can protect strongly against the same influenza type for years, while current vaccines give moderate protection for less than a year. They argue that studying natural immunity can guide vaccine designs with stronger, longer-lasting protection.
Difficult words
- antibody — protein that fights infections in the bodyantibodies
- neuraminidase — virus enzyme on the flu virus surface
- hemagglutinin — protein on flu virus important for infection
- immunity — protection in the body against a diseaseinfection-acquired immunity, infection-derived immunity
- transmission — the process of disease passing between people
- modelling — using maths to study how events change
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Why is it useful for a vaccine to reduce how much infected people spread the virus?
- How would longer-lasting protection from a vaccine change your decisions about getting vaccinated?
- What are benefits and possible concerns of studying natural (infection-derived) immunity to design vaccines?
Related articles
Mindfulness helps couples under financial stress
A University of Georgia study of over 400 couples with children found that higher mindfulness links to greater confidence the relationship will survive stress. Mindfulness also related to better relationship quality and stronger co-parenting.
Joha rice may help prevent diabetes and protect the heart
Researchers in India report that Joha, a scented short-grain rice from the northeast, showed benefits in lab and rat studies against type 2 diabetes and heart disease. Tests found healthy fats, antioxidants and improved insulin response.
Roads, isolation and more schizophrenia hospital visits
A study in New York City found that neighborhoods isolated by roads and traffic had higher rates of schizophrenia-related hospital visits. The link was independent of traffic-caused air pollution and may reflect social and planning factors.
