A study in Science Immunology reports that segmented filamentous bacteria (SFB) in the gut protected mice from lethal bacterial pneumonia after influenza A infection by reprogramming lung immune cells.
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Researchers report a modified oral vaccine made from Listeria that primes immune cells in the gut and limits tumor growth in mice. The vaccine worked best when combined with immune checkpoint inhibitors and caused few side effects.
A Washington State University study found that a lesser-known TWEAK–Fn14 pathway can join with TNF to increase inflammation. Blocking Fn14 reduced this surge and may explain why some patients do not respond to TNF inhibitors.
New research finds that repeating disruption of the body’s 24-hour clock changes breast tissue, weakens immune defenses and leads to faster, more aggressive breast cancer in experimental models. The study links altered light–dark schedules to worse outcomes.
A research team created changed antibodies that stop human cytomegalovirus from disabling immune responses. Lab tests show the antibodies reduce virus spread, but researchers say more testing is needed before they can be used in people.
Researchers found two different routes that make IgA antibodies in the gut. Early IgA often comes from non‑germinal center cells but later from germinal centers; both types showed similar specificity and mutations, which may help vaccine design.
Researchers compared infants from Old Order Mennonite farm families and urban families in New York. Farm-exposed babies showed earlier immune maturation and higher antibodies, and breast milk antibody patterns were linked to lower egg allergy risk.
A federally funded review and meta-analysis found that anti-inflammatory treatments reduced depressive symptoms and eased anhedonia in people with depression who had high inflammation. The drugs were not FDA-approved for depression and would be used off-label.