#Immunology25
Study links autoantibodies to long COVID symptoms
A new study reports that some people with long COVID make autoantibodies that attack brain and nerve tissue. When researchers gave these antibodies to mice, the animals developed pain, fatigue and balance problems similar to patient symptoms.
Photo by Shawn Day, Unsplash
Newborn antibiotics change gut bacteria and lung immunity
Researchers at University of Rochester Medicine report that antibiotics given to newborns can alter gut bacteria and reprogram lung immune cells in mice and humans. These changes can last into young adulthood and may affect breathing.
New mucosal EV vaccine with inverted HA may protect against many flu strains
Researchers report a vaccine approach using cell-derived extracellular vesicles that display inverted influenza hemagglutinin proteins. Tests in mice showed broad immune responses after intranasal dosing, suggesting potential for a universal mucosal flu vaccine.
Some chemotherapy drugs trigger immune attack by mimicking viruses
New research finds that some chemotherapy agents can make cancer cells behave like virus‑infected cells. This viral mimicry activates the innate immune system and could let doctors use lower drug doses with better results.
New oral Listeria vaccine shows promise against colorectal cancer
Researchers report a modified oral vaccine made from Listeria that primes immune cells in the gut and limits tumor growth in mice. The vaccine worked best when combined with immune checkpoint inhibitors and caused few side effects.
New inflammatory pathway may explain some rheumatoid arthritis treatment failures
A Washington State University study found that a lesser-known TWEAK–Fn14 pathway can join with TNF to increase inflammation. Blocking Fn14 reduced this surge and may explain why some patients do not respond to TNF inhibitors.