Researchers at Washington State University found a lesser-known pathway that can make inflammation worse in rheumatoid arthritis. The pathway involves a protein called TWEAK and its receptor Fn14. The team found that TWEAK–Fn14 can join with Tumor Necrosis Factor (TNF) and amplify inflammation.
The scientists studied human tissues and rat data. They also showed that blocking the Fn14 receptor reduced the sudden rise in inflammation caused by TNF. The finding may help explain why TNF inhibitors work for many patients but not for others.
Difficult words
- pathway — series of steps or actions in the body
- receptor — protein on cells that receives signals
- amplify — make something larger or stronger
- inflammation — body reaction that causes redness and pain
- inhibitor — drug or substance that slows a reactioninhibitors
- block — stop or prevent an action or signalblocking
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Have you or someone you know taken medicine for joint inflammation? What happened?
- Why might a medicine work for some patients but not for others?
- Would you want tests to find the best medicine for your illness? Why or why not?
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