Researchers used nonhuman primates infected with SIV, a virus related to HIV. The animals received long-term antiretroviral therapy that suppressed the virus, but signs of intestinal barrier problems continued.
Scientists found weaker responses in immune cells that protect and repair the gut lining. A small group of animals received a broccoli-based supplement to raise exposure to dietary indoles, compounds in vegetables of the mustard family such as broccoli and cabbage. After one month the animals showed signs of better gut barrier integrity and changes in immune cells linked to mucosal repair. The authors say the results do not prove this is a treatment for people with HIV and that more research is needed to confirm the effects in humans.
Difficult words
- primate — a mammal group including monkeys and apesnonhuman primates
- infect — to give an illness or virus to someoneinfected
- antiretroviral therapy — long-term medicine to control a virus
- intestinal barrier — tissue in the gut that stops harmful substances
- supplement — a food added to a diet for extra nutrients
- indole — a natural compound found in some vegetablesindoles
- integrity — the state of being whole or undamaged
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Do you think people should eat more vegetables like broccoli for gut health? Why?
- Why do the researchers say more research is needed before using this in people?
- Have you or someone you know taken a dietary supplement? What happened?
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