Novartis reported late-stage trial results for GanLum, a new malaria treatment that contains the molecule ganaplacide. Michael Delves of the London School of Hygiene and Tropical Medicine, who helped early development but was not involved in the trial, said the molecule is completely new and that Plasmodium has not seen it before and so has no defence.
The trial covered more than 1,600 patients across 12 countries in sub‑Saharan Africa. GanLum, given as a daily sachet of granules for three days, cured 97.4% of participants versus 94% for an existing treatment. The drug also targets the parasite as it prepares to transmit the disease to mosquitoes, which could reduce new cases and slow the spread of resistance.
Medicines for Malaria Venture, which co-developed the drug with Novartis, said regulatory approvals might take around 16 months and that the drug could reach the market in 2027. Researchers and public health experts welcomed the results.
Difficult words
- treatment — A way to help someone who is sick.treat, treatments
- promise — A belief that something will be successful.
- patient — A person receiving medical care.patients
- transmission — The act of passing something on.
- resistance — Ability to fight against something harmful.
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- What do you think about new malaria treatments?
- How important is it to prevent disease transmission?
- What challenges might GanLum face before it is approved?
Related articles
Keeping healthy habits during the holidays
The holiday season often disrupts regular health routines. Samantha Harden of Virginia Tech recommends realistic, small changes—like habit stacking, gamifying activities, involving others and travel tips—and a broader view of well‑being so breaks are not failure.
Clean water reduces child stunting in Mozambique
A University of Notre Dame study using national survey data finds that improved access to safe drinking water lowers the odds of stunting in Mozambican children by about 20%. Improved sanitation showed no independent effect on stunting.
Vigorous exercise helps sleep in older adults with mild cognitive impairment
A small Texas A&M study used Oura Rings to track seven older adults with mild cognitive impairment for 14 days. Vigorous exercise gave the largest sleep benefit; light activity helped a little and moderate exercise showed no clear effect.