Researchers report that long-lasting physical pressure on the brain can make neurons activate a self-destruct program. When many neurons die, the loss is permanent and can cause problems with sensing, movement and thinking.
In the lab, the team grew networks of neurons and glial cells from iPSCs (stem cells that become brain cells) and applied sustained pressure to copy compression found in a growing brain mass. Students compared which cells lived and which cells died under pressure.
Analysis of RNA showed increased molecules linked to stress and inflammation. Patient data and further tests on preclinical models showed similar patterns. The findings point to possible targets for drugs to protect neurons.
Difficult words
- neuron — nerve cell that sends signals in the brainneurons
- self-destruct — to activate a program that kills itself
- glial cell — support cell that helps neurons workglial cells
- stem cell — basic cell that can become many cell typesstem cells
- inflammation — body response that causes swelling and damage
- compression — pressure that pushes tissues together inside body
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Why is neuron loss a serious problem for people?
- What kinds of drug ideas could help protect neurons?
Related articles
Lower mGlu5 receptor found across autistic adult brains
A study in The American Journal of Psychiatry found lower availability of a glutamate receptor called mGlu5 across the brains of autistic adults. Researchers used PET, MRI and EEG and say the result could affect future diagnosis and treatment.
