#Cancer36
Protein linked to chemotherapy resistance in ovarian cancer
Scientists found that some ovarian cancer cells survive cisplatin chemotherapy by stabilising their internal scaffold. They identified a protein that can be blocked in laboratory tests to restore the drug's effectiveness and may serve as a biomarker.
Aging muscle may help cancer grow
Scientists found that older, weaker muscle releases fewer extracellular vesicles and less of a microRNA called miR-7a-5p. Exercise can restore vesicle release and may help reduce cancer risk in older adults. The work suggests new biomarkers and therapies.
Personalized DNA vaccine shows promise against glioblastoma
A phase 1 trial found the personalized DNA vaccine GNOS-PV01 is safe and shows early signs of activity against glioblastoma. The small study at Siteman Cancer Center and WashU Medicine reported immune responses and encouraging clinical outcomes.
Protein sensor lets MRI detect molecular activity
Researchers developed a genetically encoded protein sensor, called MAPPER, that makes molecular activity visible to MRI by changing water movement in cells. The modular system could let scientists image processes like cancer and inflammation continuously in animals.