Researchers at Rice University and Oak Ridge National Laboratory describe a new approach in The Journal of Chemical Physics that links molecular-scale motion with the signals seen in clinical MRI machines. The work focuses on contrast agents, many of which contain a gadolinium ion in an organic shell, and how these agents change the relaxation of nearby water molecules.
The NMR eigenmodes framework solves the full physical equations that govern NMR relaxation in liquids. The team used the Fokker-Planck equation to follow how probabilities of molecular positions and velocities change over time. Solving this equation lets the model capture a wide range of molecular motions and their contributions to relaxation.
The framework reproduces experimental measurements at clinical MRI frequencies with high precision. It also shows that many simplified models are special cases within a larger theory. The work grew from molecular dynamics simulations, the code is open source, and the study received support from named institutes and facilities.
Difficult words
- model — a representation or example of somethingmodels
- significant — important or meaningful in effect
- advancements — progress or improvements in knowledge
- framework — a basic structure that supports something
- dynamics — the study of forces and motion in systems
- implications — possible effects or consequences of something
- observables — things that can be seen or measuredobservable
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- How do you think this model could impact other industries?
- What are some potential applications for advancements in MRI imaging?
- Why is open-source research important in scientific advancement?
Related articles
Most US drug trials do not mirror racial and ethnic diversity
A study of pivotal trials used to approve new drugs found only a small share reflect the United States racial and ethnic makeup. The review shows underrepresentation of Black and Hispanic people and urges more diversity earlier in development.
Gene and blood‑vessel damage add to dementia risk
Researchers studied a genetic variant (APOE ε4) and white matter hyperintensities (WMH), a sign of small blood‑vessel damage. They found both factors raise dementia risk additively, and vascular health may be improved to lower that risk.
Biodegradable patch may help heart heal after heart attack
Researchers report a biodegradable microneedle patch that delivers interleukin-4 to injured heart tissue. The local treatment encourages healing immune cells, reduces scarring, and may improve heart recovery while avoiding systemic side effects.
Indigenous leader Dzoodzo Baniwa wins climate award
Dzoodzo Baniwa, from the Alto Río Negro territory in Amazonas, won a Bunge Foundation award for work on the climate emergency and practical agricultural science solutions. The prize highlights links between indigenous knowledge and scientific practice.