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Time of day may affect glioblastoma chemotherapy — Level A1 — purple and white plastic bottle

Time of day may affect glioblastoma chemotherapyCEFR A1

6 Dec 2025

Adapted from Washington U. in St. Louis, Futurity CC BY 4.0

Photo by Guido Hofmann, Unsplash

Level A1 – Beginner
2 min
63 words
  • Glioblastoma is an aggressive brain cancer.
  • It affects over 300,000 people every year.
  • Doctors use the drug temozolomide (TMZ).
  • A repair protein called MGMT can stop TMZ.
  • MGMT can be turned off by methylation.
  • MGMT levels go up and down each day.
  • Time of day may change treatment response.
  • Morning biopsies were more often scored methylated.
  • Researchers plan to test timing in clinics.

Difficult words

  • glioblastomaa serious cancer in the brain
  • aggressivefast and strong in a bad way
  • temozolomidea drug doctors use for treatment
  • proteina substance in the body
  • methylationa chemical change that turns MGMT off
  • biopsya small sample taken from the body
    biopsies

Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.

Discussion questions

  • Would you go to a clinic in the morning or afternoon for a test?
  • Do you think the time of day can change medical treatment?

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