- Glioblastoma is an aggressive brain cancer.
- It affects over 300,000 people every year.
- Doctors use the drug temozolomide (TMZ).
- A repair protein called MGMT can stop TMZ.
- MGMT can be turned off by methylation.
- MGMT levels go up and down each day.
- Time of day may change treatment response.
- Morning biopsies were more often scored methylated.
- Researchers plan to test timing in clinics.
Difficult words
- glioblastoma — a serious cancer in the brain
- aggressive — fast and strong in a bad way
- temozolomide — a drug doctors use for treatment
- protein — a substance in the body
- methylation — a chemical change that turns MGMT off
- biopsy — a small sample taken from the bodybiopsies
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Would you go to a clinic in the morning or afternoon for a test?
- Do you think the time of day can change medical treatment?
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