Researchers at Emory University tested whether two weeks of low-frequency transcranial magnetic stimulation (TMS) could lower reactivity in the amygdala, a part of the brain that processes fear, and improve PTSD symptoms. The team used MRI scans to find precise stimulation sites for each person so the treatment was personalised.
Fifty adults enrolled and 47 completed the study. Participants were randomly assigned to active TMS or a placebo in a blinded design. Compared with placebo, active TMS reduced right amygdala reactivity and led to significant symptom improvement after two weeks. The improvement lasted at least six months and 74% of the active group had meaningful symptom reduction.
Difficult words
- amygdala — a small brain part that processes fear
- reactivity — how strongly the brain reacts to things
- stimulation — an action that activates part of the body
- placebo — a treatment with no active medicine or effect
- randomly — in a way that happens by chance
- symptom — a sign that shows a person is unwellsymptoms
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Would you try a personalised treatment found with MRI? Why or why not?
- How would you feel if a treatment helped you for six months?
- Do you think a placebo can help some people? Why or why not?
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