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HIF1 protein linked to tendon pain — Level A1 — a close up of a map with the word zurch on it

HIF1 protein linked to tendon painCEFR A1

28 Feb 2026

Adapted from ETH Zurich, Futurity CC BY 4.0

Photo by Claudio Schwarz, Unsplash

Level A1 – Beginner
2 min
76 words
  • Many people have tendon pain in knees, shoulders, or elbows.
  • It affects both young athletes and older people.
  • Tendon pain often comes from too much load on tendons.
  • HIF1 is a protein found in tendon cells.
  • Higher HIF1 levels can start tendon damage.
  • Damaged tendons become stiffer and break more easily.
  • Blood vessels and nerves can grow into tendon tissue.
  • This growth helps explain why the pain appears.
  • When damage is advanced, physiotherapy may not help.

Difficult words

  • tendonstrong tissue that connects muscle to bone
    tendons
  • proteina molecule in cells that does work
  • damageharm or injury to a part of body
  • stiffnot soft, hard to bend or move
    stiffer
  • physiotherapytreatment with exercises to help the body

Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.

Discussion questions

  • Have you ever had tendon pain?
  • Do you play sports?
  • Would you try physiotherapy if you had tendon pain?

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