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HIF1 protein linked to tendon pain — Level B2 — a close up of a map with the word zurch on it
28 Feb 2026

HIF1 protein linked to tendon pain

Researchers at ETH Zurich found that part of the HIF1 protein controls gene activity in tendon cells and can trigger tendinopathy. Experiments in mice and human tissue show HIF1 remodels collagen, makes tendons brittle and may cause pain.

Photo by Claudio Schwarz, Unsplash