Researchers used experiments and computers to map single-cell activity in mouse brains. The work appears in the journal PLOS Biology. Teams in three countries contributed different parts of the study.
A lab method tagged active neurons so they glowed, and a special microscope made three-dimensional images. Mathematicians and programmers at the University of Michigan created workflows to analyse the images over time. The main result was a steady shift of activity: as mice woke, activity began deeper in the brain and later moved toward the surface. The team hopes to find signatures of fatigue that could help assess readiness for high-stakes jobs.
Difficult words
- single-cell — relating to one individual cell
- neuron — a brain cell that sends signalsneurons
- microscope — a tool that makes small things larger
- workflow — a set of steps to do workworkflows
- analyse — to study data or information carefully
- fatigue — a feeling of very great tiredness
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Have you ever used a microscope or looked at very small things? What did you see?
- Do you think checking fatigue could help people do safer jobs? Why or why not?
- How do you feel about scientists from different countries working together?
Related articles
Disposable gloves can cause false microplastic counts
University of Michigan researchers found that coatings on disposable nitrile and latex gloves can leave stearate residues that look like microplastics. The contamination can affect filters and slides used for air, water and other samples.
