Researchers used experiments and computers to map single-cell activity in mouse brains. The work appears in the journal PLOS Biology. Teams in three countries contributed different parts of the study.
A lab method tagged active neurons so they glowed, and a special microscope made three-dimensional images. Mathematicians and programmers at the University of Michigan created workflows to analyse the images over time. The main result was a steady shift of activity: as mice woke, activity began deeper in the brain and later moved toward the surface. The team hopes to find signatures of fatigue that could help assess readiness for high-stakes jobs.
Difficult words
- single-cell — relating to one individual cell
- neuron — a brain cell that sends signalsneurons
- microscope — a tool that makes small things larger
- workflow — a set of steps to do workworkflows
- analyse — to study data or information carefully
- fatigue — a feeling of very great tiredness
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- Have you ever used a microscope or looked at very small things? What did you see?
- Do you think checking fatigue could help people do safer jobs? Why or why not?
- How do you feel about scientists from different countries working together?
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