Obesity is linked to high blood pressure, but the mechanisms were unclear. Building on clinical data that associated brown fat with lower hypertension risk, researchers created mouse models that lack beige fat identity by removing Prdm16 specifically in fat cells. The mice remained otherwise healthy, avoiding obesity and inflammation, so the role of beige fat could be examined directly.
Loss of beige fat caused fat around vessels to resemble white fat and to express angiotensinogen, which leads to a hormone that raises blood pressure. The engineered mice developed higher blood pressure and mean arterial pressure. Tissue analysis showed fibrous material around vessels, and isolated arteries were highly sensitive to angiotensin II.
Single-nucleus RNA sequencing showed vascular cells switched on a fibrotic gene program. Fluid from altered fat activated those genes, and the team identified the enzyme QSOX1 as the mediator. Mice lacking both Prdm16 and Qsox1 did not develop the vascular dysfunction. Human data in large cohorts linked PRDM16 mutations to higher blood pressure, suggesting QSOX1 as a therapeutic target.
Difficult words
- beige fat — fat tissue with characteristics between brown and white
- angiotensinogen — protein that produces a hormone raising blood pressure
- hypertension — a medical condition of high blood pressure
- mean arterial pressure — average pressure in the arteries during heartbeat
- fibrotic — relating to extra fibrous tissue or scarring
- vascular — related to blood vessels in the body
- enzyme — a protein that speeds up chemical reactions
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Discussion questions
- Why did the researchers use mice that avoided obesity and inflammation in this study?
- How could identifying QSOX1 as a mediator help in developing treatments for high blood pressure?
- What differences between beige fat and white fat might matter for blood vessel health?
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