New imaging research examined brain structure in World Trade Center responders who developed long-term PTSD after the 2001 attacks. The study, published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, used MRI scans and a technique called gray-white contrast (GWC). Researchers analyzed scans from 99 responders, roughly half with PTSD and half without.
GWC measures the border between cortical gray matter and white matter. The team found that in responders with chronic PTSD, gray matter often appeared more like white matter. This pattern is consistent with changes in the balance of myelinated and unmyelinated neurons across both hemispheres. The differences were most strongly associated with re-experiencing symptoms.
Researchers also found that a sharper gray–white boundary indicated a healthy transition, while a less distinct border suggested abnormal myelin concentration and possible changes in processing speed. Combining GWC with other intracortical markers improved the ability to identify responders with PTSD. The findings point to a structural imaging parameter that may help distinguish trauma-exposed people with and without PTSD. Source: Stony Brook University.
Difficult words
- imaging — methods to create pictures of internal body
- responder — person who worked at or helped after eventsresponders
- gray-white contrast — measure of difference between cortex and white matter
- cortical — related to the brain's outer layer, the cortex
- gray matter — brain tissue mainly made of neuron cell bodies
- myelinated — having nerve fibers covered by a fatty sheath
- re-experiencing — reliving a traumatic memory or sensory moment
Tip: hover, focus or tap highlighted words in the article to see quick definitions while you read or listen.
Discussion questions
- How could an imaging test that distinguishes people with and without PTSD help doctors and patients?
- The study links brain differences to re-experiencing symptoms. How might this finding affect therapy for those symptoms?
- If scans can show structural changes after trauma, would you want to have a scan if you had symptoms? Why or why not?
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