#Immunotherapy4

31 Dec 2025

New modular CAR-T system controls where and when cells attack

Researchers at the University of Chicago created GA1CAR, a modular CAR-T system that uses short-lived Fab fragments to guide and pause tumor targeting. In animal tests the same cells were redirected to different tumors and remained functional.

A1 A2 B1 B2 Read

Photo by National Institute of Allergy and Infectious Diseases, Unsplash

29 Dec 2025

How the T cell receptor starts immune attacks

Scientists used cryo-EM and membrane-like nanodiscs to image the T cell receptor. They found it rests closed and opens when it meets a target antigen, a result that may help improve immunotherapies.

Level

A1 A2 B1 B2 Read

10 Dec 2025

Antibody therapy clears traces of multiple myeloma

A phase 2 trial found that an antibody drug, linvoseltamab, removed detectable disease in patients with multiple myeloma using very sensitive bone marrow tests. Researchers report acceptable safety and will expand the trial.

Level

A1 A2 B1 B2 Read

25 Nov 2025

Nasal nanomedicine clears deadly brain tumours in mice

Researchers used spherical nucleic acids given through the nose to deliver a STING-activating therapy that eradicated glioblastoma in mice and produced long-term immunity. The study appears in PNAS.

Level

A1 A2 B1 B2 Read

No more articles